Can Thyroid Problems Cause Schizophrenia

Can Thyroid Cause Schizophrenia

Abnormalities in thyroid hormonal status is common in major psychiatric disorders. Although the relevance of thyroid dysfunction to bipolar disorder is well-recognized, yet the association between thyroid dysfunction and schizophrenia-spectrum disorders is under-emphasized.

Sandra Hearth is the creator and writer behind “Wellbeing Port”, a blog dedicated to promoting healthy living and personal wellness. Born and raised in the bustling city of New York, Sandra has always been drawn to the idea of living a balanced and fulfilling life. As a certified health coach and yoga instructor, Sandra has a wealth of knowledge and experience in the fields of health and wellness. She started her blog as a way to share her passion for healthy living with others and to provide practical tips and advice for those looking to improve their overall wellbeing. Overall, Sandra Hearth is a knowledgeable and passionate advocate for healthy living, and her blog “Wellbeing Port” is a valuable resource for those looking to improve their health and wellbeing.

Role Of Oxidative Stress And The Identification Of Biomarkers Associated With Thyroid Dysfunction In Schizophrenics

• 1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
• 2Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
• 3Institute of Molecular Biology and Biotechnology , The University of Lahore, Lahore, Pakistan
• 4University College of Medicine and Dentistry, The University of Lahore, Lahore, Pakistan
• 5Department of Psychiatry, Ameer-Ud-Din Medical College, Lahore, Lahore, Pakistan
• 6Center for Research in Molecular Medicine, The University of Lahore, Lahore, Pakistan

Background: Schizophrenia is associated with a deficiency of dietary antioxidants like vitamin B6, B9, and B12 resulting in defective methylation leading to hyperhomocysteinemia. Hyperhomocysteinemia causes mitochondrial DNA damage, oxidative stress, vascular damage, and lipid peroxidation. Oxidative stress and increase in reactive oxygen species result in 8-oxodG production which induces apoptosis of both astrocytes and thyrocytes thus predisposing them to thyroid dysfunction and neurodegeneration. Furthermore, the presence of excessive free radicals increases thyroid thermogenesis causing hyperthyroidism or its excess may cause hypothyroidism by inhibiting iodide uptake. In the present study, we evaluated the various biomarkers associated with thyroid dysfunction in schizophrenics.

Quick Answer: Can Hyperthyroidism Cause Mental Health Issues

Hyperthyroidism is frequently associated with: irritability, insomnia, anxiety, restlessness, fatigue, impairment in concentrating and memory, these symptoms can be episodic or may develop into mania, depression and delirium. In some cases motor inhibition and apathy are symptoms that accompany hyperthyroidism.

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What Causes Anxiety In Hypothyroidism

Why are people with hypothyroidism more likely to develop anxiety? âOne theory is that simply having a physical problem like hypothyroidism can increase anxiety,â says Cheryl R. Rosenfeld, DO, a spokesperson for the American Association of Clinical Endocrinologists , partner at North Jersey Endocrine Consultants, and adjunct clinical associate professor of medicine at the Touro College of Osteopathic Medicine in New York City. âSymptoms of hypothyroidism include poor concentration, decreased memory, and difficulty performing daily activities all of which can be anxiety-producing.â

Not getting proper treatment for hypothyroidism can contribute to anxiety, as well. Levothyroxine is a common treatment for hypothyroidism, but if your dose is too high, it can directly lead to anxiety and cause symptoms like rapid heartbeat and shakiness, which can make anxiety worse, says Rosenfeld. And if hypothyroidism is not treated, symptoms like dry skin, sensitivity to cold, hoarse voice, and mood swings will persist. Over time, untreated hypothyroidism can cause heart issues like a weak pulse or heart failure, which may provoke further anxiety.

Anxiety can also make it harder to stick to your hypothyroidism treatment if it causes you to forget to take medications or causes problems going to the doctor or sticking to a healthy lifestyle.

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Open Access License / Drug Dosage / Disclaimer

This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License . Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor. The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Can Low Thyroid Cause Disorientation

There is no definitive answer to this question as the research on the matter is inconclusive. However, some experts believe that low thyroid levels can indeed cause disorientation and other cognitive problems. This is because the thyroid is responsible for regulating many important body functions, including metabolism and brain function. When thyroid levels are low, these functions can be impaired, leading to symptoms like disorientation. If you are experiencing disorientation and suspect that it may be due to low thyroid levels, it is important to see a doctor for a proper diagnosis.

How Does Hashimotos Encephalopathy Cause Psychosis

• The antibodies that the body makes against the thyroid gland might also react against nerve cells, triggering an immune response in the brain.
• The antibodies may also inflame the brains blood vessels, disrupting the flow of blood and oxygen to the brain.
• Long-term hormone disruptions from the disease can lead to secondary effects on brain functioning.

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Treating Your Thyroid Conditions

Thyroid disease can affect your mood, causing such psychological disorders as anxiety or depression. Dr. Baker and his compassionate team treat your thyroid disease, which may also provide relief from any related emotional symptoms. Depending upon your particular thyroid issues, Dr. Baker and his colleagues can help manage your health through:

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Will I Have Graves Disease For The Rest Of My Life

cure. Thyroid problems can all be treated, and normal thyroid function may be achieved. By removing the thyroid, radioactive iodine and surgery may also cure hyperthyroidism. However, since these therapies frequently have little effect on thyroid stimulating antibodies, the fundamental etiology of Graves illness continues.

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Ie Its Not All In Your Head

Believe it or not, many mental health issues are outright due to being hypothyroid , or having a cortisol problem, especially low cortisol.

No, this doesnt take away that there can be other causes of any mental health challenges. But its a common scenario for undiagnosed hypothyroid patients, no matter the cause of their hypothyroidism. Its also common for those on T4-only. And its especially common when there are issues with ones adrenals, such as now having low cortisol.

For hypothyroid patients, no matter the cause, mental health issues can be directly due to having a low free T3, the active thyroid hormone. And this is also common for patients treated with Synthroid, Levoxyl, Eltoxine, Levothyroxine, Tirosint, and other T4-only medications by themselves.

Mental health issues are also strongly connected to having low cortisol, especially as proven by a saliva cortisol test. You can order and do the latter test, its not about falling in any range. Its about where those cortisol results fall, as revealed here.

How Is Thyroid Disease Treated

Your healthcare providers goal is to return your thyroid hormone levels to normal. This can be done in a variety of ways and each specific treatment will depend on the cause of your thyroid condition.

If you have high levels of thyroid hormones , treatment options can include:

• Anti-thyroid drugs : These are medications that stop your thyroid from making hormones.
• Radioactive iodine: This treatment damages the cells of your thyroid, preventing it from making high levels of thyroid hormones.
• Beta blockers: These medications dont change the amount of hormones in your body, but they help manage your symptoms.
• Surgery: A more permanent form of treatment, your healthcare provider may surgically remove your thyroid . This will stop it from creating hormones. However, you will need to take thyroid replacement hormones for the rest of your life.

If you have low levels of thyroid hormones , the main treatment option is:

• Thyroid replacement medication: This drug is a synthetic way to add thyroid hormones back into your body. One drug thats commonly used is called levothyroxine. By using a medication, you can manage thyroid disease and live a normal life.

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How Are Thyroid Disorders Diagnosed

If you suspect your thyroid levels are either too high or too low, a doctor will conduct a physical exam and check your medical history. Theyll also check for physical symptoms such as dry skin and altered heart rate.

A blood test is the most accurate way to test for a thyroid condition. During this test, the quantity of thyroid-stimulating hormone indicates the function of your thyroid gland.

• Hypothyroidism: If your thyroid isnt producing enough hormones, your levels of TSH will be high.

• Hyperthyroidism: If your thyroid is producing too many hormones, your TSH levels will be low.

Tip : Consider A Selenium Supplement

Selenium is a trace mineral your body requires to activate thyroid hormone. Studies have linked low selenium levels with increased risks for chronic autoimmune thyroiditis, Graves disease, and goiter.

You can increase your selenium levels by increasing your intake of meat, seafood, or whole grains. But some people may require a supplement to enhance selenium levels. Talk with your doctor about what may help.

Consider scheduling an appointment with your doctor if you experience the following symptoms as they could be related to your thyroid:

• feeling a nodule or lump on either side of your larynx
• experiencing weight loss or gain that you cant explain by changes in diet or activity level
• constantly feeling very hot or very cold
• experiencing mood changes, such as depression, anxiety, or nervousness
• feeling a sense of significant fatigue

These symptoms can all indicate a potential thyroid concern and warrant a trip to your doctor.

There are two thyroid-related conditions that can be medical emergencies: myxedema coma and thyroid storm. You should seek emergency medical attention for either.

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Can Thyroid Problems Make You Feel Crazy

Thyroid problems can put you at the mercy of your moods. Too little thyroid hormone can trigger spurts of sadness or depression. On the other hand, hyperthyroidism when your body produces too much can put your emotions into overdrive, causing a jittery feeling, rapid heart rate and mind-spinning anxiety.

The Thyroid And Depression Connection

Experts arent exactly sure why, but thyroid issues can bring about symptoms of depression. In fact, a 2021 study published in Clinical Endocrinology found that people with hyperthyroidism at the start of the study were more likely to develop depression 4 years later than those with normal thyroid hormone levels.

Depression is more commonly seen with hypothyroidism but can also be seen with hyperthyroidism, along with anxiety and agitation, says Dr. Lester. And thats especially true in older adults. For example, younger people with an overactive thyroid may show signs of anxiety. This includes restlessness and chronic worry. But older adults may appear more apathetic.

What that looks like to an outside person, says Dr. Lester, is someone who sits quietly and doesnt engage much in conversation, has slowed body movements or doesnt move much. Or they sit with an inexpressive facial expression, something she says is often dubbed a masked face or flat effect.

So do depression and thyroid conditions always go hand in hand? Certainly not. In fact, its thought that most people with depression have normal thyroid function, a review published in the Journal of Thyroid Research found.

Depression can be caused by many different factors, says the National Institute of Mental Health. A family history of depression, trauma, stress and a wide range of health conditions or medications can all play a role. We answer your top questions about treating depression here.

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Can I Check My Thyroid At Home

You can do a quick and easy self-exam of your thyroid at home. The only tools you need to do this self-exam are a mirror and a glass of water.

To do the thyroid self-exam, follow these steps:

• Start by identifying where your thyroid is located. Generally, youll find the thyroid on the front of your neck, between your collar bone and Adams apple. In men, the Adams apple is much easier to see. For women, its usually easiest to look from the collar bone up.
• Tip your head back while looking in a mirror. Look at your neck and try to hone in on the space you will be looking once you start the exam.
• Once youre ready, take a drink of water while your head is tilted back. Watch your thyroid as you swallow. During this test, youre looking for lumps or bumps. You may be able to see them when you swallow the water.

Repeat this test a few times to get a good look at your thyroid. If you see any lumps or bumps, reach out to your healthcare provider.

Hashimotos Thyroiditis If Left Untreated May Lead To Imbalance Issues

Hashimotos thyroiditis is an autoimmune condition that causes your immune system to attack your thyroid gland. The condition can cause damage to your peripheral vestibular organ, a structure in your inner ear thats responsible for regulating balance.

Damage to this organ can result in short-term bouts of dizziness, particularly when you rise from a sitting or lying down position .

More research is needed to understand the relationship between autoimmune diseases and peripheral vertigo.

Any issues of dizziness or imbalance caused by untreated complications of thyroid disorders are typically resolved with treatment.

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What Types Of Thyroid Disorders Can Lead To Dizziness And Imbalance

Hypothyroidism and hyperthyroidism are two types of thyroid disorders that can cause complications most likely to result in dizziness or balance problems.

Both conditions cause irregularities in the amount of thyroid hormone thats produced and delivered into your bloodstream.

• Hypothyroidism: Hypothyroidism is when your thyroid gland is underactive and produces too few thyroid hormones.
• Hyperthyroidism: Hyperthyroidism is when your thyroid gland is overactive and produces too many thyroid hormones.

Aminoacids And Hormonal Profiles

The facts regarding different amino acids displayed a clear picture of their eminent involvement in the initiation of schizophrenia and its progression to thyroid disorders represented in . The levels of sulfur-containing amino acids were found to be significantly regulated . The homocysteine levels were significantly elevated in schizophrenics , while cysteine and methionine were significantly decreased than the control . The reason behind this variation may be due to reduced Vit B6, B9 and B12 so that homocysteine can neither be trans-sulfurated nor methylated properly resulting in oxidative stress. The levels of non-essential amino acids were markedly reduced in schizophrenics in contrast to the corresponding control while glycine was increased . The reduction in glutamate levels resulted in oxidative injury while decreased arginine levels depict a fall in NO resulting in neurocognitive decline. The essential amino acids including phenylalanine, leucine, and threonine were higher in schizophrenia patients relative to the control . The hormonal levels were also assessed. Dopamine levels were decreased while an increasing trend was observed in serotonin and prolactin among schizophrenics in comparison to the control . An increase in serotonin together with a decrease in dopamine is associated with hyperprolactinemia mediated depression .

TABLE 8. Amino acids and hormonal profile of schizophrenics versus controls.

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The Link Between Thyroid Deficiency And Psychological Dysfunction

Several psychological disorders, such as depression and anxiety, can be attributed to thyroid deficiency. There are several symptoms of these disorders, including fatigue, mental slowness, inattention, and emotional lability. As a result of hypothyroidism, many adults have cognitive issues such as increased forgetfulness, mental slowing, and brain fog. These issues may result in delirium and subsequent psychosis, known as myxedema madness, in some cases. Underactive thyroid can have a negative impact on mental well-being as well as the ability to regulate blood pressure. The Thyroid Hormone plays an important role in normal brain function.

Linking Hypothyroidism With Depression

To help your doctor figure out if your depression is because of hypothyroidism, they should test you for thyroid disorders. Blood tests can confirm them if they show low levels of a thyroid hormone called thyroxine and a high level of one called thyroid-stimulating hormone .

Studies show that if you have both hypothyroidism and depression, thyroid-replacement medications may work better than antidepressants. They boost levels of two major thyroid hormones: triiodothyronine and thyroxin . When thyroid pills lower TSH levels, you may start feeling better.

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Are There Different Types Of Thyroid Removal Surgery

If your healthcare provider determines that your thyroid needs to be removed, there are a couple of ways that can be done. Your thyroid may need to be completely removed or just partially. This will depend on the severity of your condition. Also, if your thyroid is very big or has a lot of growths on it, that could prevent you from being eligible for some types of surgery.

The surgery to remove your thyroid is called a thyroidectomy. There are two main ways this surgery can be done:

• With an incision on the front of your neck.
• With an incision in your armpit.

The incision on the front of your neck is more of the traditional version of a thyroidectomy. It allows your surgeon to go straight in and remove the thyroid. In many cases, this might be your best option. You may need this approach if your thyroid is particularly big or has a lot of larger nodules.

Alternatively, there is a version of the thyroid removal surgery where your surgeon makes an incision in your armpit and then creates a tunnel to your thyroid. This tunnel is made with a special tool called an elevated retractor. It creates an opening that connects the incision in your armpit with your neck. The surgeon will use a robotic arm that will move through the tunnel to get to the thyroid. Once there, it can remove the thyroid back through the tunnel and out of the incision in your armpit.

• Are not at a healthy body weight.
• Have large thyroid nodules.
• Have a condition like thyroiditis or Gravess disease.