Nasal Spray Research Moves To Social Anxiety Disorder
Applied Clinical Trials
Dr. Mark Smith, Chief Medical Officer of VistaGen Therapeutics, sits down with Moe Alsumidaie to discuss the challenges of modern psychiatric clinical trial design and implementation and their neuroactive pherine, PH48B.
The use of nasal spray for psychiatric indication has been recently discussed amongst many healthcare providers, as Janssen recently received FDA approval for its Esketamine nasal spray as an add-on therapy for treatment resistant depression. However, smaller biopharmaceutical enterprises are researching nasal sprays towards treating social anxiety disorder an indication that has been left alone for a longtime, even though it impacts 15 million America adults. In this inteview, Dr. Mark Smith, Chief Medical Officer of VistaGen Therapeutics, will dicusss the challenges of modern physciatric clinica trial design and implementation, as well as their novel therapeutic, PH94B.
Moe Alsumidaie: VistaGen’s drug candidate, PH94B, is in development as an on-demand treatment for SAD. Could you tell me more about how PH94B is targeting SAD? What is the mechanism of action?
MA: VistaGen ran a Pilot Phase 3 study – what is that and why did you do it?
MA: Now that you have data to support your claim for PH94B as a treatment for social anxiety disorder, how do you plan to design the Phase 3 study, and how do you plan to overcome the challenges you just unearthed?
MA: When do you expect the Phase 3 study to start?
Side Effects Requiring Immediate Medical Attention
Along with its needed effects, fluticasone nasal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking fluticasone nasal:
What About People With Heart Problems
Oftentimes, the heart doctor may overlook this topic because there are so many other things that they must bring to the patients attention, Dr. Kaminski says.
His advice? If you have high blood pressure, atrial fibrillation, supraventricular tachycardia or congestive heart failure, you should avoid OTC medicines that contain a .
Dr. Kaminski specifically recommends against using pseudoephedrine.
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Depression And Suicide: Getting Help In A Crisis
Some people who are depressed may think about hurting themselves or committing suicide . If you or someone you know is having thoughts about hurting themselves or committing suicide please seek immediate help. The following resources can help:
- Call to reach a 24hour crisis center or dial 911. is the National Suicide Prevention Lifelineexternal icon, which provides free confidential help to people in crisis. The Substance Abuse and Mental Health Services Administrationexternal icon runs this lifeline.
- Get help from your primary doctor or other health care provider.
- Reach out to a close friend or loved one.
- Contact a minister, spiritual leader, or someone else in your faith community.
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More Meds That Can Raise Blood Pressure
Besides pseudoephedrine, cold and allergy sufferers with hypertension should be wary of:
- Afrin nasal spray
- Multi-symptom cold products with NSAIDs
If you take prescription medications that increase your blood pressure, such as Adderall or albuterol inhalers, the oxymetazoline in Afrin can also increase your blood pressure through a combined effect.
NSAIDs cause the body to retain fluid and may affect kidney function, which may increase blood pressure.
Fortunately, if you have high blood pressure, there are safer alternatives when cold and allergy season come around.
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Visit Your Local Sinusitis Experts
Staying away from these common mistakes we all make when suffering from sinusitis can help your symptoms improve, but the best way to help yourself overcome sinusitis is to contact your local ENT specialists in Allen Park and Southfield. Our ENT specialists are always here to help you get through your sinus infection no matter how severe.
How Should I Use Flonase Nasal Spray
Use Flonase exactly as directed on the label, or as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Do not share this medicine with another person, even if they have the same symptoms you have.
Your dose will depend on the fluticasone brand or strength you use, and your dose may change once your symptoms improve. Follow all dosing instructions very carefully.
A child using the nasal spray should be supervised by an adult.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Shake the nasal spray just before each use.
If you switched to fluticasone from another steroid medicine, you should not stop using it suddenly. Follow your doctors instructions about tapering your dose.
It may take several days before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after a week of treatment.
Store Flonase in an upright position at room temperature, away from moisture and heat. Throw the spray bottle away after you have used 120 sprays, even if there is still medicine left in the bottle.
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What Other Information Should I Know
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Does Flonase Cause Anxiety
Horrible side effects. After using Flonase for a month, for the first time in my life i was experiencing anxiety and and panic attacks. One night i was awoken by a horrible headache and vomited. The flonase made it so hard to breathe I could only take shallow breaths and my heart rate was way higher than usual.
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Order Today And Receieve
|Though we strive to make the most effective product available, it may not work for everyone. There is no such thing as a magic pill that will get you instant cure. Every persons body responds differently. Results may vary and depend on the severity of your case, your life style and how well you follow the dosing protocol and the advice in our e-book. You should not use this information or product as a substitute for help from a licensed health professional. For those customers who do not experience significant improvement we offer 60 days FULL money back guarantee. We are committed to ethical business practices and our promise is simple: If you dont see an improvement, we do not want your money.
Higher Risk Of Nosebleeds And Sores In The Nose
- Risk factors: Long-term use | Nasal surgery | Injury to the nose | Ulcers in the nose
Rarely, using Flonase for months can cause sores to develop in the nose, which can make holes in the bony cartilage between your nostrils . Talk to your doctor if you experience painful discomfort in your nose, have regular nosebleeds, or painful sores in your nose while you use Flonase .
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The Right Way To Treat A Sinus Infection
5 min Read Time
Your head is throbbing, especially around your eyes. You cant stop coughing, and for some reason, your breath is terrible. Blowing your nose is a mess.
Bad news: You could have a sinus infection. Most frequently triggered by the common cold, over 30 million American adults are diagnosed with sinusitis yearly.
So, what exactly are sinus infections? How can you tell if you have one? And holy cow how can you feel better as quickly as possible?
How Can You Tell If You Have Chronic Sinusitis
Does it feel like your sinus infection just wont quit? If you experience at least two of the following for 12 weeks or more even though youve been treated it may be chronic sinusitis:
- A stuffed nose
- Discharge of mucus or postnasal drip
- Pain or pressure in your face
- Problems with smell
Chronic sinus infections can be triggered by colds but are typically caused by long-term inflammation. Sometimes, when treatments to control that inflammation fail, people with chronic sinusitis need surgery to drain their mucus.
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Are There Any Other Precautions Or Warnings For This Medication
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Additional medication: Although fluticasone propionate will control seasonal allergic rhinitis in most cases, an abnormally heavy amount of summer pollen may sometimes require additional treatment, particularly to control eye symptoms. Speak to your doctor if you have been using this medication for 3 weeks and are still experiencing allergic rhinitis symptoms.
Growth in children and adolescents: Corticosteroids such as fluticasone propionate nasal spray may impair the growth of children and adolescents. Your doctor will monitor for this. Talk to your doctor if you have any concerns.
Infections: Corticosteroids such as fluticasone propionate nasal spray may worsen existing infections, mask the signs of infection, and cause new infections. If you use this medication for several months or longer, your doctor will monitor you periodically for signs of infection. People who have not had chickenpox or measles or have not been vaccinated against these infections should take special care to avoid exposure to them.
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Flonase And Getting Over The Anxiety It Caused
Carriebeck over a year ago
I used Flonase for 10 days. And I know that it is not a side effect listed by the company by have had really terrible anxiety every since. It started as nervousness then a feeling like I had drank about 20 cups of coffee in a sort time. I could not relax, i was overly emotional – crying… Which is SOOOO not like me. I couldn’t eat or sleep…Then my body started tingling all over – especially the feet and legs. All of this is constant… not in waves…. At the ER they attributed it all to anxiety and said that I possibly had a reaction the steroid. That anything was possible. They gave me some good anti anxiety meds and sent me home to ride it out. So the good news is i can now sleep because of the meds but each morning when I wake up I can still feel the tingling starting to come back. And every morning I am hopeful it’s just going to be over and I won’t have to take more drugs. Can anyone who has experienced the similar tell me how long it was until you felt normal? I stopped it 5 days ago! I’m getting worried I am never going to feel normal again.
Roland over a year ago
Roland over a year ago
Carriebeck over a year ago
Guest over a year ago
Guest over a year ago
Guest over a year ago
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Risk Overview Of Fluticasone Treatments
How you take fluticasone depends on what you want it to do. Some forms of fluticasone treatment are higher risk for anxiety sufferers than others. The list below provides an overview of the different types of fluticasone treatments and which you will most want to avoid if you are prone to anxiety and/or panic attacks.
Fluticasone is used in three different forms to treat three different types of ailment. These include:
Does Flonase Raise Blood Sugar
These include oxymetazoline , phenylephrine , and xylometazoline . Since these nasal sprays are less fully absorbed into the bloodstream than are the oral agents, they should have less effect on blood sugar levels. This class of drugs has no effect on blood sugar.
Subsequently, question is, what medications can raise blood sugar levels? Some common medications that can increase glucose levels:
- Valium and Ativan
- Catecholamines, which include the EpiPen and asthma inhalers.
Moreover, can diabetics take Flonase?
CONCLUSION: Intranasal corticosteroids seem to have no adverse effects on HbA1c and serum glucose levels in diabetic patients. Their long-term use appears to be safe, provided that the patients are carefully monitored, especially those receiving triamcinolone acetonide.
Does flonase raise blood pressure?
When used as directed, FLONASE products do not increase blood pressure.
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Please Review This Safety Information
Below you can learn about the risks and side effects of BREO ELLIPTA. This, however, is not all the safety information and does not replace your talking to your healthcare professional about your medical condition or treatment. Please see the complete Prescribing Information, including Patient Information, for BREO ELLIPTA for more information, or ask your healthcare provider or pharmacist.
What Are The Long
The likelihood of experiencing adverse Avamys side effects increases if you use this nasal spray regularly for long periods of time.
The below are thought to be long-term effects of taking Avamys:
- Increase in nosebleeds
- Slowing or suppression of growth in children
- Blurred vision or changes to vision such as cataracts or glaucoma
- Chest tightness causing difficulty in breathing
- Cushings syndrome, Cushingoid features or adrenal suppression
Nasal corticosteroids like Avamys can affect the production of hormones in the body especially if you use strong doses for a long period of time. Particularly in children, this side effect may cause slower growth or suppression in normal growth.
More rarely, there may be psychological or behavioural effects such as sleep disorders, hyperactivity, anxiety, depression or aggression .
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Warning Disclaimer Use For Publication
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Is Pseudoephedrine Safe Why Is It Sold Behind The Counter
Pseudoephedrine is safe and effective when taken as directed. But some people use OTC pseudoephedrine illegally. They combine it with other products to make methamphetamine . Meth is an illegal and dangerous street drug. To help keep people from making meth, OTC medicines that contain pseudoephedrine are sold behind the counter. In most states, you dont need a prescription from your doctor to buy these medicines. But you will have to ask your pharmacist for them. Additional restrictions include:
- Limit on the amount you can purchase each month.
- You must show photo identification when purchasing the medicine.
- Stores must record and keep personal information about customers who buy the medicine.
Some states have more requirements for medicines containing pseudoephedrine. These requirements may include a doctors prescription.
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Can Oxymetazoline Cause Anxiety
Regarding this, what are the side effects of Oxymetazoline?
Check with your doctor immediately if any of the following side effects occur while taking oxymetazoline nasal:
- Blurred vision.
- fast, irregular, or pounding heartbeat.
- headache, dizziness, drowsiness, or lightheadedness.
- high blood pressure.
- increase in runny or stuffy nose.
- trouble in sleeping.
Also, what happens if you use too much Oxymetazoline? Too much oxymetazoline nasal could be very harmful. Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.
Herein, can nasal spray cause anxiety?
All of these adverse reactions can mimic the symptoms of anxiety, and in sensitive individuals, may even precipitate panic attacks. While oral decongestant drugs may be more likely to lead to unwanted side effects, decongestant nasal sprays may also cause side effects to a lesser extent.
Does Afrin give you anxiety?
Perhaps that combined with the Afrin — which can cause nervousness and other nervous system effects — lowered some threshold.
What Happens If You Overuse Flonase
Nasal spray addiction is not a true addiction, but it can lead to tissue damage inside the nose. This can result in swelling and long-term stuffiness that leads to further use and overuse of the spray. In some cases, a person may need to undergo additional treatment, and possibly surgery, to correct any damage.
Afrin Allergy Sinus Nasal Spray Congestion Relief 1 Ct 05 Oz
Afrin Allergy Sinus 12 Hour Nasal Decongestant Spray reduces swelling of nasal passages to provide fast, powerful, medicated nasal and sinus congestion relief. Delivering a mist of relief, this medicated sinus and allergy nasal spray starts working instantly, alleviating nasal congestion from the common cold, hay fever and other upper respiratory allergies. Just two or three quick and firm sprays in each nostril provide 12 hours of nasal congestion relief for adults and children 6 to 12 years with adult supervision.
- One box of 15 mL Afrin Allergy Sinus 12 Hour Nasal Decongestant Spray
- Allergy and sinus nasal spray that starts working instantly to relieve swelling of nasal passages
- Alleviates nasal congestion from the common cold, hay fever and other upper respiratory allergies
- 12 hour sinus and allergy relief from colds or allergies
- Afrin nasal spray bottle is easy to use, delivering instant relief
- Afrin is for adults, as well as children 6+