Wellbutrin And Zoloft: How Are They Similar
Both Wellbutrin Zoloft can help to regulate mood and treat depressive symptoms. They are available in generic and brand name versions. Both are prescription drugs that come in the form of oral tablets to be taken by mouth. They can be used long-term by depressed patients. Wellbutrin / Zoloft are both approved for use in adolescents and adults.
Zoloft, or any other SSRIs, and bupropion should not be taken together with a monoamine oxidase inhibitor . Examples of monoamine oxidase inhibitors are isocarboxazid, phenelzine, selegiline, and procarbazine. A 14-day wash-out period when switching between Zoloft, Wellbutrin, and an MAO inhibitor is crucial to avoid serotonin syndrome. Serotonin syndrome can cause confusion, tremors, high blood pressure, coma, and even death. This is a medical emergency that requires urgent medical care.
What Is A Selective Serotonin Reuptake Inhibitor
Selective serotonin reuptake inhibitors are a group of commonly prescribed antidepressant drugs that inhibit the reabsorption of serotonin by neurons. Serotonin is a chemical messenger in the brain that works as a mood stabilizer. By increasing the availability of serotonin, SSRIs help to regulate mood. Zoloft is an SSRI.
Wellbutrin belongs to a different class of medications called NDRIs . NDRIs and SSRIs act similarly, i.e., they boost the levels of certain chemicals called neurotransmitters in the brain. However, SSRIs such as Zoloft boost serotonin levels. NDRIs such as Wellbutrin boost norepinephrine and dopamine levels.
Are Lexapro And Wellbutrin Safe To Take If I Am Pregnant Or Breastfeeding
- The safety of Lexapro during pregnancy and breastfeeding has not been established. Therefore, Lexapro should not be used during pregnancy unless, in the opinion of the physician, the expected benefits to a patient outweigh unknown hazards to the fetus.
- Lexapro is excreted in human milk. Lexapro should not be given to nursing mothers unless, in the opinion of the physician, the expected benefits to the patient outweigh the possible hazards to the child.
- There are no adequate studies of bupropion in pregnant women. In one study, there was no difference between bupropion and other antidepressants in the occurrence of birth defects. Bupropion should only be used in pregnancy if the benefit outweighs the potential risk.
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Does Wellbutrin Cause Anxiety
Some people experience the following symptoms when they start taking Wellbutrin:
- Feeling agitated
- Unexplained excitement
Studies show that around 2% on Wellbutrin stopped treatment with this medication due to symptoms that are related to anxiety. Some of the above-mentioned symptoms were serious enough to warrant the use of sedative and/or anti-anxiety medication to calm the patients.
These anxiety-like side effects may be caused by the quick dosage increase of the medication.
Prescription Of Wellbutrin For Anxiety
There are several reasons FDA has approved Wellbutrin for anxiety, these reasons are :
- Quitting smoking
- Seasonal affective disorder
- Major depressive disorder
However, the exact reason for which Wellbutrin is used to treat conditions like these is not determined. It is not known how it works against such diseases. It is believed to affect levels of mood influencing chemicals such as dopamine or norepinephrine.
This is slightly different from other types of antidepressants which affect the levels of serotonin in the body. Sometimes doctors also prescribe Wellbutrin for some other conditions that are off-label. Off-label here means that they are not approved by FDA. These off-label conditions include:
- Neuropathic pain.
- Attention deficit hyperactivity disorder or ADHD.
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Wellbutrin Vs Zoloft: Differences Similarities And Which Is Better For You
Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ
Wellbutrin and Zoloft are two prescription medications indicated in the treatment of major depressive disorder . MDD is one of the most common mental health conditions in the United States. It is characterized by a period of two weeks or more where a person experiences a depressed mood or loss of interest in activities that typically elicit happiness.
MDD is also typically accompanied by troubles with sleeping, eating, concentrating, and energy. Wellbutrin works by increasing available dopamine and norepinephrine, while Zoloft increases available serotonin. While both drugs work to treat depression, they do so by acting on different neurotransmitters which affect mood.
Understanding Wellbutrin And Anxiety: Cause And Treatment
Wellbutrin, known for its generic name bupropion, is an antidepressant with several on and off-label uses. It is FDA-approved for the treatment of depression, specifically, major depressive disorder . It is, as a matter of fact, the go-to for the treatment of depression. It is also approved for the treatment of seasonal affective disorder in addition to being indicated as an effective smoking cessation aid.
Experts have yet to understand how exactly Wellbutrin works to treat and manage depression. However, it is thought that the therapeutic effects are a result of the drug increasing the levels of specific neurotransmitters in the brain, namely dopamine and norepinephrine. These neurotransmitters help to improve mood, memory, concentration and sleep.
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What Other Treatment Options And Resources Are Available For Social Anxiety Disorder
CBT can also be a first-choice treatment for people with social anxiety disorder. During CBT, people are encouraged to focus their attention outward instead of on themselves to help reframe their thoughts about social situations. Multiple studies suggest that CBT significantly improves social anxiety symptoms.
According to the ADAA, the most effective part of CBT involves exposing people to feared social situations . CBT that includes exposure therapy is an effective option for managing multiple types of anxiety conditions, including social anxiety disorder.
For some people, combining CBT with medications may help manage social anxiety disorder. A randomized controlled trial showed that adding CBT to antidepressants was successful in relieving anxiety symptoms in almost 50% of people with social anxiety disorder who continued to have symptoms despite taking medications.
Support or self-help groups can also be helpful for some people in managing this condition. In these settings, people are encouraged to share their challenges and accomplishments with others dealing with similar problems.
Support groups are available both in-person and online. Although internet forums and chat rooms can be accessed easily, you should talk with your healthcare provider before following any medical or mental health advice that you receive online.
There are also different resources available to help you get connected with therapies for managing social anxiety disorder:
When To Take Wellbutrin For Anxiety
Are you trying to manage your anxiety and considering taking Wellbutrin?
There is some confusing information out there about Wellbutrin and its side effects and uses, so its important to understand whether this medication suits you and your situation.
Have you considered clinical trials for Anxiety?
We make it easy for you to participate in a clinical trial for Anxiety, and get access to the latest treatments not yet widely available – and be a part of finding a cure.
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Drug Interactions Of Wellbutrin Vs Zoloft
Wellbutrin and Zoloft each have multiple possible drug interactions primarily due to their metabolism by the cytochrome P450 system. Wellbutrin, for instance, potently inhibits CYP2D6, and therefore doses of CYP2D6 substrates may need to be decreased in patients taking Wellbutrin. Examples of CYP2D6 substrates include codeine, haloperidol, risperidone, and metoprolol. Zoloft is a minor inhibitor of CYP2D6 and may cause the same interactions but to a lesser degree.
Other drugs with serotonergic actions when combined with Zoloft may increase the risk for serotonin syndrome. Serotonin syndrome is the result of abnormally high levels of free serotonin and can result in agitation, dizziness, and increased heart rate.
Zoloft may cause a specific type of cardiac arrhythmia known as a prolonged QTc interval when taken with certain classes of medication. It is important that your healthcare professional and pharmacist have a complete list of medications you are taking in order to appropriately screen for potential interactions.
The following list is not intended to be a complete list of drug interactions. Your doctor or pharmacist can provide a complete list.
When To See A Doctor
If your depression symptoms return for more than a few days, it’s time to see your doctor. But even if you feel like your antidepressant isn’t working, it’s important to keep taking it until your doctor advises otherwise. You may need a dosage increase or a slow tapering off process. With many antidepressant medications, stopping their use too quickly can cause withdrawal effects such as:
- Greater anxiety
- Suicidal thoughts
Early warning signs of breakthrough depression are the symptoms you typically experience when an episode of depression is coming on, says Nestadt. Depression symptoms vary from person to person, but signs include:
- Low mood
- Changes in sleep or appetite
- Loss of interest in previously enjoyable activities
If your symptoms return, don’t worry adjusting the dose or switching to another antidepressant often solves the problem.
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Bupropion For Smoking Cessation
Studies reveal bupropion to be a great aid for smoking cessation as it helps reduce nicotine withdrawal and cravings to a great extent.
The type of bupropion used for smoking cessation is sold under the brand name of Zyban. It is described as a safe and cost-effective treatment for nicotine addiction. Zyban helps around one in 5 people quit smoking in the U.S each year. The effectiveness of this medication as an aid against nicotine dependence increases when bupropion is used in conjunction with other nicotine replacement products such as the nicotine patch, gum, and lozenges. However, Zyban may only be recommended for people who smoke ten or more cigarettes per day.
What Are The Side Effects Of Wellbutrin In Children
Wellbutrin isnt approved for use in children. The drug is approved for use only in adults ages 18 years and older. However, Wellbutrin may be prescribed for children off-label.
Its important to note that Wellbutrin has a about the risk of suicidal thoughts and behaviors in children, teens, and young adults. A boxed warning is the most serious warning from the Food and Drug Administration .
For details, you can see the Side effects up close section right below.
Your childs medical professional can give you more information about Wellbutrin off-label use in children.
Heres some additional information about some of the side effects that Wellbutrin may cause.
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How Does Wellbutrin Work
Wellbutrin is a norepinephrine and dopamine reuptake inhibitor , and it works by keeping the neurotransmitters norepinephrine and dopamine available to the brains neurons for longer. This helps improve concentration, focus, and other ADHD symptoms. Since Wellbutrin does not influence serotonin, it works differently than many other antidepressants.
For example, selective serotonin reuptake inhibitors affect serotonin, whereas tricyclic antidepressants increase norepinephrine and serotonin levels and block acetylcholine, which can lead to side effects. Monoamine oxidase inhibitors the first antidepressantsincrease norepinephrine, serotonin, and dopamine by suppressing the enzyme monoamine oxidase.
Is Wellbutrin Good For Social Anxiety
Bupropion has been evaluated for the use of generalized social phobia. People who took this medicine reported feeling much improved or very much improved after 12 weeks of treatment. This medication was generally well tolerated. Findings from this study suggest that bupropion-SR can be useful in treating generalized social phobia.
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Wellbutrin Storage & Disposal
Wellbutrin should be kept at room temperature and away from light, excess heat and moisture. Keep it in a child proof container in a safe location that is out of reach and sight of children to prevent access for young children.
Medication that is not needed anymore should be disposed of properly to ensure that other people, children and pets are not able to consume it. If you are unsure of how to dispose of the medication, contact your doctor or your local pharmacist.
Possible Side Effects Of Wellbutrin For Anxiety
When you start taking Wellbutrin regularly, during the first few weeks or initial weeks you may face certain side effects. These side effects will often reduce after time. They include:
- trouble while sleeping
- quick heartbeat
Along with these minor side effects of Wellbutrin for anxiety, sometimes the side effects can be severe, one of these severe side effects is seizures. The risk of having seizures is often greater in individuals who:
- Have a previous history of seizures
- Are consuming higher doses of Wellbutrin
- Having an injury or tumor in their brain
- Have liver disorder like cirrhosis
- Having eating disorders like bulimia or anorexia
- are dependant too much on alcohol or drugs
- on other medications that could escalate the risk of acquiring seizures
Some additional serious side effects of Wellbutrin may include all of these:
- Increase in suicidal thoughts in case of adults and children.
- Manic episodes mostly in people already having bipolar dsorder
- Halluciations, delusions, and paranoia.
- Hypertension or high blood pressure.
- Eye problems such as swelling, redness, and eye pain.
- Severe allergic reactions.
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Antipsychotics For Ordinary Depression
âIâm taking an antidepressant, but Iâm still not where I want to be with my symptoms.â
If that line sounds familiar, itâs because you might have heard it in recent television commercials for the powerful psychiatric drug aripiprazole . Originally approved to treat the disabling mental illnesses of schizophrenia and bipolar disorder, Abilify is now, with permission from the Food and Drug Administration, being pitched to people with depression who havenât gotten relief from milder drugs such as SSRIs.
In December 2009, Abilifyâs competitor quetiapine succeeded in winning the same approval as an add-on for depression.
The mass marketing of hard-core psychiatric drugs is worrisome, said Julie Donohue, Ph.D., an assistant professor at the University of Pittsburgh Graduate School of Public Health. âPeople might think from the commercial that everybodyâs going to get better, when really itâs a minority of patients who respond to the treatment,â she said.
Another issue is that the studies conducted to secure Abilifyâs approval as a depression add-on lasted only six weeks. âThat means we donât know the long-term benefits or harms of the drug for this use, which is a problem because people will take Abilify for monthsand probably years,â said Steven Woloshin, M.D., a professor of medicine at Dartmouth Medical School.
Something else the ads donât mention is the cost of the drugs: up to 45 times as much as many antidepressants.
Do Wellbutrin And Lexapro Interact Together
Managing your mental health can feel like a part-time job. Keeping up with taking medication, understanding its side effects, and tracking your experiences for your doctor or psychiatrist can be overwhelming.
On top of that, if youre feeling like your anxiety or depression symptoms arent improving, you might be searching for options you can discuss with your prescribing care provider.
If youre wondering whether Wellbutrin and Lexapro are medications you can combine for your treatment, keep reading. Well also show you a few more alternatives to help you manage your symptoms while youre figuring things out.
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You’ve Got Tons Of Energy All Of A Sudden
This can be a perk of the drug for women who want to feel more energized. But Ackerman warns: Theres a risk of flipping someone into hypomania or mania if they have an underlying bipolar disorder.” It’s for this reason, Ackerman adds, that Wellbutrin wouldn’t be used in bipolar patients, unless it was paired with a mood stabilizer.
How Much Weight Will You Use Using Wellbutrin By Itself
If Wellbutrin is going to work for you, studies indicate that you will probably lose about 2-10% of your initial body weight .
That means if you are 200 pounds the best-case scenario is that Wellbutrin helps you lose 20 pounds.
If you are only 150 pounds, its possible that Wellbutrin may only help you lose a couple of pounds.
These numbers may not sound great at first but you have to realize that this data stems from the use of Wellbutrin as monotherapy .
As with any other weight loss medication I highly recommend against this strategy.
Its far better to use MULTIPLE therapies at once or to combine medications to get a synergistic effect.
By adding a medication known as Naltrexone you can increase weight loss and expand the number of people that will benefit from taking these medications.
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Benefits Of Taking Wellbutrin
Although there may be common to severe side effects, taking Wellbutrin has several benefits:
- There is no known side effects from long terms use of this drug
- Compared to other antidepressants, Wellbutin has less sexual side effects, such as decreased libido
- It is very effective in treating seasonal affective disorder and major depressive disorder
- It helps people to stop smoking
What Other Treatments Can Help Manage Anxiety
Medications for anxiety are safe and effective and are good options for many people. But some people want to avoid medication, and some want to combine medication with other treatments. You can try:
- Psychotherapy. Cognitive behavioral therapy is a first-line treatment for anxiety, and phobias can respond to biofeedback and exposure therapy.
- Stress management techniques. You can learn breathing techniques and progressive muscle relaxation to reduce anxiety.
- Lifestyle modifications. Getting enough quality sleep, exercising, and avoiding alcohol, illicit drugs and excessive caffeine can help reduce anxiety.
- Support groups. Connecting with people who share your experiences can be valuable.
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